Triệu chứng, biểu hiện dị ứng thuốc

Bạn đã biết khi bị dị ứng thuốc sẽ có những triệu chứng, biểu hiện nào chưa? Sau đây là một số biểu hiện dị ứng thuốc. Các bạn cùng tham khảo nhé!

biểu hiện dị ứng thuốc
biểu hiện dị ứng thuốc

Triệu chứng, biểu hiện dị ứng thuốc

Các phản ứng dị ứng có nhiều cấp độ khác nhau, từ nhẹ nhất là sự kích ứng, các tác dụng phụ ở mức độ nhẹ như: buồn nôn, nôn mửa cho đến các trường hợp nặng có thể đe dọa tính mạng, chẳng hạn shock phản vệ… Sau đây là các biểu hiện dị ứng thuốc thường gặp nhất:

1. Mày đay: Là biểu hiện lâm sàng nhẹ và ban đầu của phần lớn các trường hợp dị ứng thuốc. Sau khi dùng thuốc (nhanh từ 5-10 phút, chậm có thể vài ngày), người bệnh cảm thấy nóng bừng, ngứa, trên da nổi ban cùng sẩn phù. Trường hợp nặng có thể có khó thở, đau bụng, đau khớp, chóng mặt, buồn nôn, đau đầu, mệt mỏi, sốt cao…

Xem thêm:

Cách điều trị viêm da dị ứng thời tiết ở trẻ em

Cách chữa trị dị ứng da mặt đơn giản hiệu quả

Mẹo chữa dị ứng thời tiết đơn giản tại nhà

2. Phù Quincke: Là tình trạng phù cục bộ, phù thường xuất hiện nhanh sau khi dùng thuốc ở những vùng da mỏng, môi, cổ, quanh mắt, bụng, các chi, bộ phận sinh dục… Màu da vùng phù bình thường hoặc hơi hồng nhạt, đôi khi phối hợp với mày đay. Trường hợp phù Quincke ở họng, thanh quản, người bệnh có thể bị nghẹt thở; ở ruột, dạ dày gây đau bụng; ở não gây đau đầu…

3. Viêm da dị ứng: Thương tổn cơ bản là mụn nước kèm theo ban đỏ, ngứa, phù da và tiến triển theo nhiều giai đoạn. Viêm da dị ứng có thể xuất hiện nhanh sau một vài giờ, trung bình sau vài ba ngày, có khi hàng tuần sau khi dùng hoặc tiếp xúc với thuốc.

4. Đỏ da toàn thân: Bệnh xuất hiện từ 2 – 3 ngày, trung bình 6 – 7 ngày, đôi khi 2 – 3 tuần sau khi dùng thuốc. Người bệnh thấy bừng nóng, ngứa khắp người, sốt cao, rối loạn tiêu hóa, nổi ban đỏ toàn thân, trên da có vảy trắng, các kẽ chân tay có thể nứt và chảy nước vàng, đôi khi bị bội nhiễm có mủ.

5. Bệnh huyết thanh: Thường xuất hiện vào ngày thứ hai đến ngày thứ 14 sau khi dùng thuốc với biểu hiện  dị ứng thuốc thường mệt mỏi, chán ăn, mất ngủ, buồn nôn, đau khớp, sưng nhiều hạch, sốt cao 38 – 39oC, gan to, nổi ban mày đay khắp người. Nếu phát hiện kịp thời và ngừng ngay việc dùng thuốc, các triệu chứng trên sẽ dần hết.

6. Chứng mất bạch cầu hạt: Biểu hiện lâm sàng điển hình là sốt cao đột ngột, mệt mỏi, sức khỏe giảm sút nhanh, nổi ban dạng sởi, dạng xuất huyết, loét hoại tử niêm mạc miệng, mũi họng, cơ quan sinh dục, viêm phổi, viêm tắc tĩnh mạch, nhiễm xuất huyết dễ dẫn tới tử vong.

7. Hồng ban đa dạng: Bệnh bắt đầu sau một vài ngày dùng thuốc với những biểu hiện: sốt nhẹ, mệt mỏi, đau khớp, sưng hạch, có cảm giác nóng bỏng toàn thân, trên da xuất hiện các sẩn tròn giống sẩn mày đay, rìa nổi gờ cao, đỏ hơi cộm, vùng trung tâm của sẩn hơi lõm và nhăn. Ngoài sẩn còn có các mụn nước, bọng nước, tổn thương niêm mạc các hốc tự nhiên, tổn thương nội tạng… trường hợp nặng có thể gây tử vong.

8. Hội chứng Stevens-Johnson (hồng ban đa dạng có bọng nước): Sau khi dùng thuốc từ vài giờ đến 10 – 15 ngày, người bệnh mệt mỏi, ngứa khắp người, có cảm giác nóng ran, sốt cao, nổi ban đỏ, nổi bọng nước trên da, viêm loét hoại tử niêm mạc các hốc tự nhiên và có thể kèm theo tổn thương gan thận, nếu biểu hiện dị ứng thuốc này nặng có thể gây tử vong.

9. Hội chứng Lyell: Là tình trạng nhiễm độc da dị ứng nghiêm trọng nhất. Bệnh diễn biến từ vài giờ đến vài tuần sau khi dùng thuốc. Người bệnh mệt mỏi, mất ngủ, sốt cao, ngứa khắp người, trên da xuất hiện các mảng đỏ; vài ngày sau, lớp thượng bì tách khỏi tổ chức da, khẽ động đến là tuột từng mảng, tương tự hội chứng bỏng toàn thân; tình trạng người bệnh thường rất nặng, nhanh dẫn đến tử vong.

10. Sốc phản vệ: Là tai biến dị ứng nghiêm trọng, dễ gây tử vong. Biểu hiện lâm sàng đa dạng, có thể xảy ra ngay sau khi dùng thuốc vài giây cho đến 20 – 30 phút, khởi đầu bằng cảm giác lạ thường (tê môi, lưỡi, bồn chồn, sợ hãi…). Tiếp đó là sự xuất hiện nhanh các triệu chứng như khó thở, mạch nhanh nhỏ, huyết áp tụt, ngứa ran khắp người, đau quặn bụng, tiểu tiện, đại tiện không tự chủ, thể cấp tính người bệnh có thể hôn mê, nghẹt thở, rối loạn nhịp tim, ngừng tim và tử vong sau ít phút.

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