Dùng thuốc chống dị ứng và những điều cần biết

  Bệnh dị ứng chính là biểu hiện của phản ứng quá mẫn cơ thể đối với dị nguyên. Các chất có thể gây nên tình trạng dị ứng như: thức ăn, hoa quả, cây cỏ, bụi bặm, lông gia súc, hóa chất, vi khuẩn, nấm… kể cả thuốc điều trị các loại bệnh. Các con đường đưa các chất gây dị ứng vào cơ thể như: ăn, uống, tiêm, hít, ngửi, nhỏ mắt, tiếp xúc qua da…

   Khi gặp phải những dấu hiệu của bệnh dị ứng, bạn có thể nhờ đến sự can thiệp của các loại thuốc chống dị ứng để giảm nhanh các triệu chứng của tình trạng này. Tuy nhiên, để có được hiệu quả điều trị tốt nhất bạn cần tuân thủ theo hướng dẫn và chỉ định của thầy thuốc để tránh chúng gây hại đến sức khỏe của bạn.

Các loại thuốc chống dị ứng thường gặp

   Thuốc chống bệnh dị ứng là các loại thuốc chống lại hoặc đối kháng lại quá trình quá mẫn của cơ thể đối với dị nguyên.  Thuốc có tác dụng ức chế sự tác động của chất trung gian gây bệnh dị ứng là histamine. Có hai thế hệ thuốc cơ bản là thuốc thế hệ 1 (còn được gọi là thế hệ kinh điển, thế hệ cũ) và thế hệ 2 (còn được gọi là thế hệ mới). Có thể kể ra đây một số loại như clopheniramin, cetirizin, diphenylhydramin, loratadin, fexodenadin…

Các loại thuốc chống dị ứng thường gặp
Các loại thuốc chống dị ứng thường gặp

Tác dụng phụ của thuốc chống dị ứng

  Hiện nay các cơ sở dược phẩm thường sản xuất các loại thuốc điều trị bệnh cảm cúm thông thường có phối hợp với thuốc chống dị chứng kháng histamin H1 cổ điển nên rất dễ có nguy cơ gây nên những phản ứng phụ không mong muốn đã nêu trên cho người sử dụng mà hậu quả dẫn đến tai nạn giao thông và tai nạn lao động có thể xảy ra bất cứ lúc nào mà không lường trước được.

Tác dụng phụ của thuốc chống dị ứng
Tác dụng phụ của thuốc chống dị ứng

   Vì vậy mọi người cần lưu ý khi sử dụng các loại thuốc cảm cúm thông thường như Decolgen, Panadol…; trong đó có thành phần paracetamol hay acetaminophen giúp giảm đau, hạ sốt kết hợp với thuốc kháng histamin H1 cổ điển như chlorpheniramine có tác dụng giúp chống viêm mũi dị ứng hoặc một số thuốc khác kết hợp với thuốc dextromethorphan giúp giảm ho.

Những lưu ý khi dùng thuốc chống dị ứng

1. Một số loại thuốc chống dị ứng không nên dùng ban ngày

   Thuốc chống bệnh dị ứng thế hệ 1 như clopheniramin thì không nên dùng ban ngày vì chúng dễ thấm vào thần kinh trung ương, có nguy cơ gây buồn ngủ. Bạn nên uống vào buổi tối, khi không phải làm việc.

2. Tránh dùng thuốc chống dị ứng với bệnh nhân tim mạch

    Thuốc chống dị ứng vẫn được coi là những thuốc an toàn nhưng một số loại thuốc thế hệ 2 có thể gây ra một số biến cố trên tim mạch như gây xoắn đỉnh, tức là tim tự nhiên ngừng đập sau một chu kỳ. Điều này là nguy hiểm vì nó có thể gây thiếu máu cơ tim. Với những bệnh nhân có rối loạn tim mạch thì không nên dùng một số thuốc thế hệ hai như astemizol.

3. Ngộ độc do quá liều

    bệnh dị ứng gây ngứa râm ran khắp người nên một phản xạ là dùng nhiều thuốc liều cao cho đỡ ngứa. Điều đáng nói là liều ngộ độc của thuốc chống bệnh dị ứng không cách quá xa liều điều trị. Biểu hiện của ngộ độc là khô miệng như ngói, đỏ rực như thịt bò, nóng như hòn than, phát cuồng như kẻ mất trí và nháy mắt liên tục như cánh dơi. Liều khuyên dùng của thuốc thế hệ 2 là chỉ dùng 1 viên/ ngày, dùng quá 4 viên/ ngày rất nguy hiểm.

Ngộ độc do quá liều
Ngộ độc do quá liều

4. Không trộn nhiều loại

    Các thuốc chống  bệnh dị ứng dù có các loại loại khác nhau thì đều có chung một cơ chế tác động đó là tranh chấp vị trí tác động với chất trung gian hóa học gây dị ứng histamine. Việc tranh chấp với histamine chỉ phụ thuộc vào nồng độ chất đó cao hay thấp chứ không phụ thuộc vào có nhiều loại thuốc hay ít loại thuốc. Dùng nhiều loại thuốc đã không tạo ra hiệu quả tăng hơn mà lại còn làm nặng nề thêm chuyển hóa cho gan thì đó là việc rất không nên dùng.

5. Không uống chung thuốc chống dị ứng với thuốc trị nấm

   Thuốc chống dị ứng không nên dùng với thuốc trị nấm như itraconnazole (Sporanox) hay ketoconazole (Nizoral). Vì thuốc này ức chế hoạt động của enzyme chuyển hóa thuốc chống nấm tại gan nên thuốc chống nấm sẽ chậm được chuyển hóa và chậm bị đào thải. Điều này dẫn đến người bệnh bị ngộ độc thuốc trị nấm ở ngay liều điều trị an toàn, nhất là những người phải dùng thuốc trị nấm kéo dài.

Không uống chung thuốc chống dị ứng với thuốc trị nấm
Không uống chung thuốc chống dị ứng với thuốc trị nấm

6. Hạn chế tối đa dùng thuốc chống dị ứng cho trẻ em

   Thuốc chống dị ứng, đặc biệt thuốc dạng thế hệ 1 như clopheniramin thấm vào thần kinh trung ương ở não nên làm ức chế sự phát triển của não bộ ảnh hưởng tới quá trình hình thành tư duy ở trẻ. Với trẻ em đến trường, thuốc làm giảm khả năng tập trung, giảm khả năng tiếp nhận, giảm khả năng tư duy nên hiệu quả học tập giảm sút.

   Trong trường hợp phải dùng thuốc thì chỉ được dùng rất ngắn trong 1-2 ngày và nhất định phải có sự tham vấn của bác sĩ.

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